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Science 9 December 1983:
Vol. 222. no. 4628, pp. 1132 - 1135
DOI: 10.1126/science.6417790
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Articles

Science, Vol 222, Issue 4628, 1132-1135
Copyright © 1983 by American Association for the Advancement of Science

articles

alpha-Difluoromethylornithine-induced polyamine depletion of 9L tumor cells modifies drug-induced DNA cross-link formation

PJ Tofilon, DF Deen, and LJ Marton

Depletion of intracellular levels of polyamines, which are believed to have a role in the intranuclear stabilization of DNA, alters the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum II in 9L rat brain tumor cells. Alkaline elution techniques were used to show that polyamine depletion alters the number of DNA cross-links formed by these cytotoxic agents.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)