Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 9 December 1983:
Vol. 222. no. 4628, pp. 1125 - 1127
DOI: 10.1126/science.6316502
Prev | Table of Contents | Next

Articles

Science, Vol 222, Issue 4628, 1125-1127
Copyright © 1983 by American Association for the Advancement of Science

articles

Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line

P Clapham, K Nagy, R Cheingsong-Popov, M Exley, and RA Weiss

Human T-cell leukemia virus (HTLV), American PL isolate, was transmitted by cocultivation and by cell-free filtrates to a nonlymphoid human osteogenic sarcoma (HOS) cell line, designated HOS/PL, but not to nine other lines bearing receptors for HTLV. HOS and HOS/PL cells are not dependent on interleukin-2 and do not express interleukin-2 receptors that are recognized by anti-Tac monoclonal antibody. HTLV released by the Japanese MT2 cell line was also transmitted to HOS cells. The infected HOS cells release substantial titers of progeny HTLV which is antigenically indistinguishable from parental virus and is able to transform T cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human T-Cell Leukemia Virus Type 1 Infection Leads to Arrest in the G1 Phase of the Cell Cycle.
M. Liu, L. Yang, L. Zhang, B. Liu, R. Merling, Z. Xia, and C.-Z. Giam (2008)
J. Virol. 82, 8442-8455
   Abstract »    Full Text »    PDF »
Tetraspanins in Viral Infections: a Fundamental Role in Viral Biology?.
F. Martin, D. M. Roth, D. A. Jans, C. W. Pouton, L. J. Partridge, P. N. Monk, and G. W. Moseley (2005)
J. Virol. 79, 10839-10851
   Full Text »    PDF »
Expression of Glucose Transporter 1 Confers Susceptibility to Human T-Cell Leukemia Virus Envelope-Mediated Fusion.
A. K. Coskun and R. E. Sutton (2005)
J. Virol. 79, 4150-4158
   Abstract »    Full Text »    PDF »
The CC Chemokine Receptor 4 as a Novel Specific Molecular Target for Immunotherapy in Adult T-Cell Leukemia/Lymphoma.
T. Ishida, S. Iida, Y. Akatsuka, T. Ishii, M. Miyazaki, H. Komatsu, H. Inagaki, N. Okada, T. Fujita, K. Shitara, et al. (2004)
Clin. Cancer Res. 10, 7529-7539
   Abstract »    Full Text »    PDF »
Human T-Cell Leukemia Virus Type 1 Envelope Glycoprotein gp46 Interacts with Cell Surface Heparan Sulfate Proteoglycans.
J. D. Pinon, P. J. Klasse, S. R. Jassal, S. Welson, J. Weber, D. W. Brighty, and Q. J. Sattentau (2003)
J. Virol. 77, 9922-9930
   Abstract »    Full Text »    PDF »
A role for CD1d-restricted NKT cells in injury-associated T cell suppression.
D. E. Faunce, R. L. Gamelli, M. A. Choudhry, and E. J. Kovacs (2003)
J. Leukoc. Biol. 73, 747-755
   Abstract »    Full Text »    PDF »
Similar Regulation of Cell Surface Human T-Cell Leukemia Virus Type 1 (HTLV-1) Surface Binding Proteins in Cells Highly and Poorly Transduced by HTLV-1-Pseudotyped Virions.
K. S. Jones, M. Nath, C. Petrow-Sadowski, A. C. Baines, M. Dambach, Y. Huang, and F. W. Ruscetti (2002)
J. Virol. 76, 12723-12734
   Abstract »    Full Text »    PDF »
Examining Human T-Lymphotropic Virus Type 1 Infection and Replication by Cell-Free Infection with Recombinant Virus Vectors.
D. Derse, S. A. Hill, P. A. Lloyd, H.-k. Chung, and B. A. Morse (2001)
J. Virol. 75, 8461-8468
   Abstract »    Full Text »    PDF »
HTLV-1-induced cell fusion is limited at two distinct steps in the fusion pathway after receptor binding.
S Daenke and S Booth (2000)
J. Cell Sci. 113, 37-44
   Abstract »    PDF »
Inhibition of Cell-Free Human T-Cell Leukemia Virus Type 1 Infection at a Postbinding Step by the Synthetic Peptide Derived from an Ectodomain of the gp21 Transmembrane Glycoprotein.
A. Jinno, Y. Haraguchi, H. Shiraki, and H. Hoshino (1999)
J. Virol. 73, 9683-9689
   Abstract »    Full Text »    PDF »
Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I.
P. Hollsberg (1999)
Microbiol. Mol. Biol. Rev. 63, 308-333
   Abstract »    Full Text »    PDF »
Syncytium-Inhibiting Monoclonal Antibodies Produced against Human T-Cell Lymphotropic Virus Type 1-Infected Cells Recognize Class II Major Histocompatibility Complex Molecules and Block by Protein Crowding.
J. E. K. Hildreth (1998)
J. Virol. 72, 9544-9552
   Abstract »    Full Text »    PDF »
Human Complement Component C1q Inhibits the Infectivity of Cell-Free HTLV-I.
F. Ikeda, Y. Haraguchi, A. Jinno, Y. Iino, Y. Morishita, H. Shiraki, and H. Hoshino (1998)
J. Immunol. 161, 5712-5719
   Abstract »    Full Text »    PDF »
Factors Secreted by Human T Lymphotropic Virus Type I (HTLV-I)-infected Cells Can Enhance or Inhibit Replication of HIV-1 in HTLV-I-uninfected Cells: Implications for In Vivo Coinfection with HTLV-I and HIV-1.
H. Moriuchi, M. Moriuchi, and A. S. Fauci (1998)
J. Exp. Med. 187, 1689-1697
   Abstract »    Full Text »    PDF »
71-Kilodalton Heat Shock Cognate Protein Acts as a Cellular Receptor for Syncytium Formation Induced by Human T-Cell Lymphotropic Virus Type 1.
Y. Sagara, C. Ishida, Y. Inoue, H. Shiraki, and Y. Maeda (1998)
J. Virol. 72, 535-541
   Abstract »    Full Text »    PDF »
Pathogenesis of Diseases Induced by Human Lymphotropic Virus Type I Infection.
P. Hollsberg and D. A. Hafler (1993)
N. Engl. J. Med. 328, 1173-1182
   Full Text »
Human T cell leukemia viruses use a receptor determined by human chromosome 17.
M. Sommerfelt, B. Williams, P. Clapham, E Solomon, P. Goodfellow, and R. Weiss (1988)
Science 242, 1557-1559
   Abstract »    PDF »
HIV-1 production from infected peripheral blood T cells after HTLV-I induced mitogenic stimulation.
J. Zack, A. Cann, J. Lugo, and I. Chen (1988)
Science 240, 1026-1029
   Abstract »    PDF »
U3 sequences from HTLV-I and -II LTRs confer pX protein response to a murine leukemia virus LTR.
H Kitado, I. Chen, N. Shah, A. Cann, K Shimotohno, and H Fan (1987)
Science 235, 901-904
   Abstract »    PDF »
Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression.
W. Greene, W. Leonard, Y Wano, P. Svetlik, N. Peffer, J. Sodroski, C. Rosen, W. Goh, and W. Haseltine (1986)
Science 232, 877-880
   Abstract »    PDF »
Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay.
S Harada, Y Koyanagi, and N Yamamoto (1985)
Science 229, 563-566
   Abstract »    PDF »
Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells.
J. Sodroski, C. Rosen, and W. Haseltine (1984)
Science 225, 381-385
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)