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Science 25 November 1983:
Vol. 222. no. 4626, pp. 935 - 937
DOI: 10.1126/science.6415815
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Articles

Science, Vol 222, Issue 4626, 935-937
Copyright © 1983 by American Association for the Advancement of Science

articles

Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor

Y Tache, Y Goto, MW Gunion, W Vale, J River, and M Brown

Intracisternal injection of ovine corticotropin-releasing factor (CRF) into the pylorus-ligated rat or the rat with gastric fistula resulted in a dose-dependent inhibition of gastric secretion stimulated with pentagastrin or thyrotropin-releasing hormone. When injected into the lateral hypothalamus--but not when injected into the cerebral cortex--CRF suppressed pentagastrin-stimulated acid secretion. The inhibitory effect of CRF was blocked by vagotomy and adrenalectomy but not by hypophysectomy or naloxone treatment. These results indicate that CRF acts within the brain to inhibit gastric acid secretion through vagal and adrenal mechanisms and not through hypophysiotropic effects.


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