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Science 25 November 1983:
Vol. 222. no. 4626, pp. 931 - 933
DOI: 10.1126/science.6356364
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Articles

Science, Vol 222, Issue 4626, 931-933
Copyright © 1983 by American Association for the Advancement of Science

articles

Erythrocyte form of spectrin in cerebellum: appearance at a specific stage in the terminal differentiation of neurons

E Lazarides and WJ Nelson

The developing chicken cerebellum contains two forms of the plasma membrane-associated actin-binding protein spectrin. The brain form, alpha gamma-spectrin (fodrin), is expressed constitutively in all neuronal cell bodies and processes during all stages of cerebellar morphogenesis. On the other hand, the erythrocyte form, alpha beta'beta-spectrin, accumulates exclusively at the plasma membrane of the cell bodies of Purkinje and granule cells and of neurons in cerebellar nuclei, but only after these cells have become postmitotic and have completed their migration to their final positions in the cerebellum. The appearance of alpha beta'beta-spectrin coincides temporally with the establishment of axosomatic contacts on these three neuronal cell types, which suggests that alpha beta'beta-spectrin accumulates in response to the formation of functional synaptic connections during cerebellar ontogeny.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The 270 kDa splice variant of erythrocyte beta-spectrin (beta I sigma 2) segregates in vivo and in vitro to specific domains of cerebellar neurons.
F Malchiodi-Albedi, M Ceccarini, J. Winkelmann, J. Morrow, and T. Petrucci (1993)
J. Cell Sci. 106, 67-78
   Abstract »    PDF »
Immunological approaches to the nervous system.
L. Reichardt (1984)
Science 225, 1294-1299
   Abstract »    PDF »


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