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Science 18 November 1983:
Vol. 222. no. 4625, pp. 794 - 799
DOI: 10.1126/science.6314503
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Articles

Science, Vol 222, Issue 4625, 794-799
Copyright © 1983 by American Association for the Advancement of Science

articles

Modulation of synapse formation by cyclic adenosine monophosphate

M Nirenberg, S Wilson, H Higashida, A Rotter, K Krueger, N Busis, R Ray, JG Kenimer, and M Adler

Synapses between neuroblastoma-hybrid cells and myotubes exhibit a high degree of plasticity. Increase of cyclic adenosine monophosphate (AMP) levels of the hybrid cells for several days results in the appearance of functional voltage-sensitive Ca2+ channels, which are required for evoked secretion of acetylcholine. The results show that cyclic AMP regulates synaptogenesis by regulating the expression of voltage-sensitive Ca2+ channels, and suggest that cyclic AMP affects posttranslational modifications of some glycoproteins and cellular levels of certain proteins.


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