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Science 18 November 1983:
Vol. 222. no. 4625, pp. 788 - 794
DOI: 10.1126/science.6356361
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Articles

Science, Vol 222, Issue 4625, 788-794
Copyright © 1983 by American Association for the Advancement of Science

articles

Surface molecules identify groups of growing axons

RD McKay, S Hockfield, J Johansen, I Thompson, and K Frederiksen

Studies on vertebrate and invertebrate species have established that, during development, axons have the ability to choose particular paths over others. The chemical basis of this pathfinding is not clear but biochemical differences between neurons have long been postulated to account for the specificity of neuronal connections. Such subtle molecular differences between different cells in a single tissue are difficult to study with standard biochemical techniques but hybridoma technology has offered a potential solution to this type of problem. This technique has made possible the production of monoclonal antibodies for identifying and characterizing a family of glycoproteins which are expressed on the surface of specific axon bundles during the development of the leech nervous system. The results show that groups of growing axons do indeed carry chemically distinct surface molecules.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Differential Glycosylation of Tractin and LeechCAM, Two Novel Ig Superfamily Members, Regulates Neurite Extension and Fascicle Formation.
Y. Huang, J. Jellies, K. M. Johansen, and J. Johansen (1997)
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Growth cone guidance in insects: fasciclin II is a member of the immunoglobulin superfamily.
A. Harrelson and C. Goodman (1988)
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A Mab to a unique cerebellar neuron generated by immunosuppression and rapid immunization.
S Hockfield (1987)
Science 237, 67-70
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The changing view of neural specificity.
S. Easter Jr, D Purves, P Rakic, and N. Spitzer (1985)
Science 230, 507-511
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Cell recognition during neuronal development.
C. Goodman, M. Bastiani, C. Doe, S du Lac, S. Helfand, J. Kuwada, and J. Thomas (1984)
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