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Science 18 November 1983:
Vol. 222. no. 4625, pp. 740 - 748
DOI: 10.1126/science.6356356
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Articles

Science, Vol 222, Issue 4625, 740-748
Copyright © 1983 by American Association for the Advancement of Science

articles

Transcription of class III genes: formation of preinitiation complexes

AB Lassar, PL Martin, and RG Roeder

Class III genes require multiple cellular factors for transcription by RNA polymerase III; these genes form stable transcription complexes, which in the case of Xenopus 5S genes are correlated with differential expression in vivo. The minimal number and identity of the factors required to form both stable and metastable complexes on three class III genes (encoding, respectively, 5S RNA, transfer RNA, and adenovirus VA RNA species) were determined. Stable complex formation requires one common factor, whose recognition site was analyzed, and either no additional factors (the VA gene), a second common factor (the transfer RNA gene), or a third gene-specific factor (the 5S gene). The mechanism of stable complex formation and its relevance to transcriptional regulation were examined in light of the various factors and the promoter sequences recognized by these factors.


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Specific regulation of Xenopus chromosomal 5S rRNA gene transcription in vivo by histone H1..
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The role of transcription factors, chromatin structure and DNA replication in 5 S RNA gene regulation.
A. Wolffe (1994)
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Ty3 integrates within the region of RNA polymerase III transcription initiation..
D L Chalker and S B Sandmeyer (1992)
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Sarkosyl defines three intermediate steps in transcription initiation by RNA polymerase III: application to stimulation of transcription by E1A..
R Kovelman and R G Roeder (1990)
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Oocyte and somatic tyrosine tRNA genes in Xenopus laevis..
F Stutz, E Gouilloud, and S G Clarkson (1989)
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Y Y Xing and A Worcel (1989)
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Positive and negative regulation of the gene for transcription factor IIIA in Xenopus laevis oocytes..
K W Scotto, H Kaulen, and R G Roeder (1989)
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Developmental regulation of two 5S ribosomal RNA genes.
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S. Bell, R. Learned, H. Jantzen, and R Tjian (1988)
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Changing directions in Pol III transcription..
W R Folk (1988)
Genes & Dev. 2, 373-375
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TFIIIA binds with equal affinity to somatic and major oocyte 5S RNA genes..
G A McConkey and D F Bogenhagen (1988)
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Multiple DNA-protein interactions governing high-precision DNA transactions.
H Echols (1986)
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Plasticity of the differentiated state.
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Transcription of class III genes activated by viral immediate early proteins.
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