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Science 4 November 1983:
Vol. 222. no. 4623, pp. 524 - 527
DOI: 10.1126/science.6312563
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Articles

Science, Vol 222, Issue 4623, 524-527
Copyright © 1983 by American Association for the Advancement of Science

articles

Detection of antibodies to herpes simplex virus with a continuous cell line expressing cloned glycoprotein D

PW Berman, D Dowbenko, LA Lasky, and CC Simonsen

The gene for glycoprotein D of herpes simplex virus type 1 (HSV-1) was expressed in stable mammalian cell lines. Glycoprotein D produced in these cells has a number of antigenic determinants in common with the native glycoprotein. Cell lines expressing glycoprotein D were used in an enzyme-linked immunosorbent assay to detect human antibodies to glycoprotein D. This strategy should prove useful in determining the extent to which the immune response to HSV-1 is directed toward glycoprotein D.


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Herpes Simplex Virus Infection: Biology, Treatment, and Prevention.
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Ann Intern Med 103, 404-419
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