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Science 28 October 1983:
Vol. 222. no. 4622, pp. 430 - 432
DOI: 10.1126/science.6604943
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Articles

Science, Vol 222, Issue 4622, 430-432
Copyright © 1983 by American Association for the Advancement of Science

articles

Identification of the c-myc oncogene product in normal and malignant B cells

A Giallongo, E Appella, R Ricciardi, G Rovera, and CM Croce

Antiserum to a synthetic peptide corresponding to the carboxyl-terminus of the human c-myc protein immunoprecipitated a 48,000-dalton protein from a number of normal and malignant human and mouse cells. The size of the protein is consistent with the potential coding region predicted from the c-myc nucleotide sequence, and is the same for malignant cells carrying either a rearranged or an unrearranged c-myc oncogene. Because c-myc transcripts are expressed at higher levels in malignant than in normal B cells, it appears that an increased level of the c-myc protein rather than a change in the gene product is the relevant factor in determining transformation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Genetic Analysis of Human Lymphoid Neoplasms: Immunoglobulin Genes and the c-myc Oncogene.
T. A. WALDMANN, S. J. KORSMEYER, A. BAKHSHI, A. ARNOLD, and I. R. KIRSCH (1985)
Ann Intern Med 102, 497-510
   Abstract »    PDF »
Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation.
H Persson, L Hennighausen, R Taub, W DeGrado, and P Leder (1984)
Science 225, 687-693
   Abstract »    PDF »
Expression of cellular oncogenes in human malignancies.
D. Slamon, J. deKernion, I. Verma, and M. Cline (1984)
Science 224, 256-262
   Abstract »    PDF »


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