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Science 28 October 1983:
Vol. 222. no. 4622, pp. 428 - 430
DOI: 10.1126/science.6623084
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Articles

Science, Vol 222, Issue 4622, 428-430
Copyright © 1983 by American Association for the Advancement of Science

articles

Noninvasive observations of fluorinated anesthetics in rabbit brain by fluorine-19 nuclear magnetic resonance

AM Wyrwicz, MH Pszenny, JC Schofield, PC Tillman, RE Gordon, and PA Martin

Fluorinated anesthetics were observed noninvasively in the brain of intact rabbits with fluorine-19 nuclear magnetic resonance spectroscopy. High-resolution fluorine-19 spectra of halothane, methoxyflurane, and isoflurane were obtained with a surface coil centered over the calvarium. Elimination of halothane from the brain was also monitored by this technique. Residual fluorine-19 signals from halothane (or a metabolite) could be detected as long as 98 hours after termination of anesthesia. These observations demonstrate the feasibility of using this technique to study the fate of fluorinated anesthetics in live mammals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Interactions Between Inhaled Anesthetics and Proteins.
R. G. Eckenhoff and J. S. Johansson (1997)
Pharmacol. Rev. 49, 343-368
   Abstract »    Full Text »    PDF »
Elimination of anesthetics from rabbit brain.
D. Strum, B. Johnson, and E. Eger 2nd (1986)
Science 234, 1586-1588
   PDF »
Response: Elimination of Anesthetics from Rabbit Brain.
A. M. WYRWICZ (1986)
Science 234, 1587-1588
   PDF »


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