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Science 28 October 1983:
Vol. 222. no. 4622, pp. 423 - 426
DOI: 10.1126/science.6623082
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Articles

Science, Vol 222, Issue 4622, 423-426
Copyright © 1983 by American Association for the Advancement of Science

articles

Monoclonal antibodies in the lymphatics: selective delivery to lymph node metastases of a solid tumor

JN Weinstein, MA Steller, AM Keenan, DG Covell, ME Key, SM Sieber, RK Oldham, KM Hwang, and RJ Parker

After subcutaneous injection, monoclonal antibodies directed against a tumor can enter local lymphatic vessels, pass to the draining lymph nodes, and bind to metastases there. Lymphatic delivery of antibody to early metastases is more efficient than intravenous administration, and the lymphatic route can be used to image smaller metastatic deposits. Perhaps more important, the lymphatic route minimizes binding of antibodies to circulating tumor antigens and to cross-reactive antigens present on normal tissues. Antibodies inappropriate for intravenous use because of binding to normal tissues may therefore be useful against lymph node metastases when injected subcutaneously or directly into lymphatic vessels.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dual-Labeled Trastuzumab-Based Imaging Agent for the Detection of Human Epidermal Growth Factor Receptor 2 Overexpression in Breast Cancer.
L. Sampath, S. Kwon, S. Ke, W. Wang, R. Schiff, M. E. Mawad, and E. M. Sevick-Muraca (2007)
J. Nucl. Med. 48, 1501-1510
   Abstract »    Full Text »    PDF »
Monoclonal Antibodies for Treating Cancer.
R. O. Dillman (1989)
Ann Intern Med 111, 592-603
   Abstract »    PDF »
Erratum.
(1983)
Science 222, 566
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)