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Science 28 October 1983:
Vol. 222. no. 4622, pp. 422 - 423
DOI: 10.1126/science.6623081
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Articles

Science, Vol 222, Issue 4622, 422-423
Copyright © 1983 by American Association for the Advancement of Science

articles

Benzoquinolinediones: activity as insect teratogens

BT Walton, C Ho, CY Ma, EG O'Neill, and GL Kao

Morphological abnormalities including extra compound eyes, extra heads, and distally duplicated legs were generated in cricket embryos by treating eggs with single doses of either benz[g]isoquinoline-5,10-dione or benzo[h]quinoline-5,6-dione. Slight structural modifications of the molecules resulted in a loss of teratogenic activity, although embryotoxicity occurred. These potent insect teratogens can be used for analysis of developmental events during embryogenesis.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)