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Science 21 October 1983:
Vol. 222. no. 4621, pp. 333 - 335
DOI: 10.1126/science.6623080
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Articles

Science, Vol 222, Issue 4621, 333-335
Copyright © 1983 by American Association for the Advancement of Science

articles

Sex differences in serotonin 1 receptor binding in rat brain

CT Fischette, A Biegon, and BS McEwen

Male and female rats exhibit sex differences in binding by serotonin 1 receptors in discrete areas of the brain, some of which have been implicated in the control of ovulation and of gonadotropin release. The sex-specific changes in binding, which occur in response to the same hormonal (estrogenic) stimulus, are due to changes in the number of binding sites. Castration alone also affects the number of binding sites in certain areas. The results lead to the conclusion that peripheral hormones modulate binding by serotonin 1 receptors. The status of the serotonin receptor system may affect the reproductive capacity of an organism and may be related to sex-linked emotional disturbances in humans.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Association Between Serotonin Transporter Gene Promoter Polymorphism (5HTTLPR) and Behavioral Responses to Tryptophan Depletion in Healthy Women With and Without Family History of Depression.
A. Neumeister, A. Konstantinidis, J. Stastny, M. J. Schwarz, O. Vitouch, M. Willeit, N. Praschak-Rieder, J. Zach, M. de Zwaan, B. Bondy, et al. (2002)
Arch Gen Psychiatry 59, 613-620
   Abstract »    Full Text »    PDF »
Effects of the Menstrual Cycle on Dependent Variables in Mood Disorder Research.
E. Leibenluft, P. L. Fiero, and D. R. Rubinow (1994)
Arch Gen Psychiatry 51, 761-781
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Effects of food deprivation and mCPP treatment on the microstructure of ingestive behaviour of male and female rats.
P.G. Clifton, A.M. Barnfield, and G. Curzon (1993)
J Psychopharmacol 7, 257-264
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The Psychobiology of Female Aggression.
D. H. FISHBEIN (1992)
Criminal Justice and Behavior 19, 99-126
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