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Science 21 October 1983:
Vol. 222. no. 4621, pp. 330 - 332
DOI: 10.1126/science.6623079
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Articles

Science, Vol 222, Issue 4621, 330-332
Copyright © 1983 by American Association for the Advancement of Science

articles

Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells

Farley JR, JE Wergedal, and DJ Baylink

Fluoride is one of the most potent but least well understood stimulators of bone formation in vivo. Bone formation was shown to arise from direct effects on bone cells. Treatment with sodium fluoride increased proliferation and alkaline phosphatase activity of bone cells in vitro and increased bone formation in embryonic calvaria at concentrations that stimulate bone formation in vivo.


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