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Science 14 October 1983:
Vol. 222. no. 4620, pp. 173 - 175
DOI: 10.1126/science.6623066
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Articles

Science, Vol 222, Issue 4620, 173-175
Copyright © 1983 by American Association for the Advancement of Science

articles

Normal cells of patients with high cancer risk syndromes lack transforming activity in the NIH/3T3 transfection assay

SW Needleman, Y Yuasa, S Srivastava, and SA Aaronson

Oncogenes capable of transforming NIH/3T3 cells are often present in human tumors and tumor cell lines. Such oncogenes were not detected in normal fibroblast lines derived from patients with several clinical syndromes associated with greatly increased cancer risk. Thus, germ-line transmission of these oncogenes does not appear to be the predisposing factor responsible for these high cancer risk syndromes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family.
E. Chang, K. Pirollo, Z. Zou, H. Cheung, E. Lawler, R Garner, E White, W. Bernstein, J. Fraumeni Jr, and W. Blattner (1987)
Science 237, 1036-1039
   Abstract »    PDF »
Detection of a cellular oncogene in spontaneous liver tumors of B6C3F1 mice.
T. Fox and P. Watanabe (1985)
Science 228, 596-597
   Abstract »    PDF »


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