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Science 7 October 1983:
Vol. 222. no. 4619, pp. 69 - 72
DOI: 10.1126/science.6623058
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Articles

Science, Vol 222, Issue 4619, 69-72
Copyright © 1983 by American Association for the Advancement of Science

articles

Intracellular recordings from cochlear inner hair cells: effects of stimulation of the crossed olivocochlear efferents

MC Brown, AL Nuttall, and RI Masta

Intracellular recordings were obtained from inner hair cells located in the lower basal turn of the guinea pig cochlea. At low sound pressure levels the inner hair cells were highly frequency selective, producing receptor potentials only in response to sound frequencies between about 16 and 24 kilohertz. Electrical stimulation of efferent nerves in the crossed olivocochlear bundle markedly reduced these receptor potentials while causing little change in the resting membrane potential. At high sound levels, where cells responded to an increasingly wider range of sound frequencies, stimulation was less effective in reducing receptor potentials. Since the crossed olivocochlear bundle primarily innervates outer hair cells, these results support an outer hair cell contribution to the most sensitive response region of inner hair cells.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)