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Science 7 October 1983:
Vol. 222. no. 4619, pp. 65 - 67
DOI: 10.1126/science.6623056
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Articles

Science, Vol 222, Issue 4619, 65-67
Copyright © 1983 by American Association for the Advancement of Science

articles

Type II collagen-induced autoimmune endolymphatic hydrops in guinea pig

TJ Yoo, Y Yazawa, K Tomoda, and R Floyd

Endolymphatic hydrops was induced in guinea pigs by immunizing them with native bovine type II collagen. Histopathologic changes consisted of moderate extension of the Reissner's membrane, spiral ganglion degeneration, atrophied organ of Corti, and mild atrophy of the surface epithelium in the endolymphatic duct. These findings suggest that an immune response directed against type II collagen--a type of collagen found in the membranous labyrinth, subepithelial layer of the endolymphatic duct, spiral ligament, and enchondral layer of the otic capsule--may induce endolymphatic hydrops.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Increased Frequencies of Cochlin-Specific T Cells in Patients with Autoimmune Sensorineural Hearing Loss.
M.-J. Baek, H.-M. Park, J. M. Johnson, C. Z. Altuntas, D. Jane-wit, R. Jaini, C. A. Solares, D. M. Thomas, E. J. Ball, N. G. Robertson, et al. (2006)
J. Immunol. 177, 4203-4210
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