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Science 7 October 1983:
Vol. 222. no. 4619, pp. 60 - 62
DOI: 10.1126/science.6194561
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Articles

Science, Vol 222, Issue 4619, 60-62
Copyright © 1983 by American Association for the Advancement of Science

articles

Neuron-glia adhesion is inhibited by antibodies to neural determinants

M Grumet, U Rutishauser, and GM Edelman

Suspensions of embryonic chick neuronal cells adhered to monolayers of glial cells, but few neurons bound to control monolayers of fibroblastic cells from meninges or skin. Neuronal cell-glial cell adhesion was inhibited by prior incubation of the neurons with Fab' fragments of antibodies to neuronal membranes. In contrast, antibodies to the neural cell adhesion molecule (N-CAM) did not inhibit the binding. These results suggest that a specific adhesive mechanism between neurons and glial cells exists and that it is mediated by CAM's that differ from those so far identified.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)