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Science 30 September 1983:
Vol. 221. no. 4618, pp. 1407 - 1409
DOI: 10.1126/science.6612350
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Articles

Science, Vol 221, Issue 4618, 1407-1409
Copyright © 1983 by American Association for the Advancement of Science

articles

Pregnancy interception with a combination of prostaglandins: studies in monkeys

JW Wilks

Treatment with combinations of synthetic prostaglandins, one with an ovarian site of action and one with a uterine site of action, terminated pregnancy in all rhesus monkeys given the injection on day 28 of fertile menstrual cycles. Single prostaglandins, even at higher doses, interrupted pregnancy in only one-third of the monkeys. The most effective treatment, 5-oxa-17-phenyl-18,19,20-trinor prostaglandin F1 alpha methyl ester plus 9-deoxo-16,16-dimethyl-9-methylene prostaglandin E2, promptly intercepted early pregnancy after a single administration and without side effects.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genome-Wide Gene Expression Analysis Reveals a Dynamic Interplay between Luteotropic and Luteolytic Factors in the Regulation of Corpus Luteum Function in the Bonnet Monkey (Macaca radiata).
S. Priyanka, P. Jayaram, R. Sridaran, and R. Medhamurthy (2009)
Endocrinology 150, 1473-1484
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Science. ISSN 0036-8075 (print), 1095-9203 (online)