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Science 30 September 1983:
Vol. 221. no. 4618, pp. 1405 - 1406
DOI: 10.1126/science.6684328
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Articles

Science, Vol 221, Issue 4618, 1405-1406
Copyright © 1983 by American Association for the Advancement of Science

articles

Carbocyclic arabinofuranosyladenine (cyclaradine): efficacy against genital herpes in guinea pigs

R Vince, S Daluge, H Lee, WM Shannon, G Arnett, TW Schafer, TL Nagabhushan, P Reichert, and H Tsai

Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5'-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)