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Science 23 September 1983:
Vol. 221. no. 4617, pp. 1307 - 1310
DOI: 10.1126/science.6612347
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Articles

Science, Vol 221, Issue 4617, 1307-1310
Copyright © 1983 by American Association for the Advancement of Science

articles

Modulation of the metastatic capability in B16 melanoma by cell shape

A Raz and A Ben-Ze'ev

The lung colonization of B16-F1 cells grown in flat and spherical configurations was studied. Cells cultivated in vitro as spheroids on a nonadhesive substrate expressed in a reversible fashion a marked increase in their propensity to establish metastases. The altered metastatic capability was accompanied by a reversible reduction in the accessibility of cell surface proteins to external iodination and by a dramatic decrease in the synthesis of vimentin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Anoikis and Metastatic Potential of Cloudman S91 Melanoma Cells.
Z. Zhu, O. Sanchez-Sweatman, X. Huang, R. Wiltrout, R. Khokha, Q. Zhao, and E. Gorelik (2001)
Cancer Res. 61, 1707-1716
   Abstract »    Full Text »
Modulation of the metastatic activity of melanoma cells by laminin and fibronectin.
V. Terranova, J. Williams, L. Liotta, and G. Martin (1984)
Science 226, 982-985
   Abstract »    PDF »
Dynamic heterogeneity: rapid generation of metastatic variants in mouse B16 melanoma cells.
R. Hill, A. Chambers, V Ling, and J. Harris (1984)
Science 224, 998-1001
   Abstract »    PDF »


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