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Science 23 September 1983:
Vol. 221. no. 4617, pp. 1301 - 1304
DOI: 10.1126/science.6612346
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Articles

Science, Vol 221, Issue 4617, 1301-1304
Copyright © 1983 by American Association for the Advancement of Science

articles

Stress-induced suppression of immunity in adrenalectomized rats

SE Keller, JM Weiss, SJ Schleifer, NE Miller, and M Stein

Stress-induced suppression of lymphocyte stimulation by phytohemagglutinin was demonstrated in Isolated lymphocytes and in cultures of whole blood from adrenalectomized rats. The results demonstrate that corticosteroid independent mechanisms participate in the suppression of lymphocyte function by stressors. Stress-induced lymphopenia, however, was found to be adrenal dependent, indicating that the modulation of immunity by stress is complex and multidetermined.


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