Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 23 September 1983:
Vol. 221. no. 4617, pp. 1299 - 1301
DOI: 10.1126/science.6612345
Prev | Table of Contents | Next

Articles

Science, Vol 221, Issue 4617, 1299-1301
Copyright © 1983 by American Association for the Advancement of Science

articles

Acetylcholine mediates a slow synaptic potential in hippocampal pyramidal cells

AE Cole and RA Nicoll

The hippocampal slice preparation was used to study the role of acetylcholine as a synaptic transmitter. Bath-applied acetylcholine had three actions on pyramidal cells: (i) depolarization associated with increased input resistance, (ii) blockade of calcium-activated potassium responses, and (iii) blockade of accommodation of cell discharge. All these actions were reversed by the muscarinic antagonist atropine. Stimulation of sites in the slice known to contain cholinergic fibers mimicked all the actions. Furthermore, these evoked synaptic responses were enhanced by the cholinesterase inhibitor eserine and were blocked by atropine. These findings provide electrophysiological support for the role of acetylcholine as a synaptic transmitter in the brain and demonstrate that nonclassical synaptic responses involving the blockade of membrane conductances exist in the brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nonsynaptic Chemical Transmission Through Nicotinic Acetylcholine Receptors.
B. Lendvai and E. S. Vizi (2008)
Physiol Rev 88, 333-349
   Abstract »    Full Text »    PDF »
Gonadal Steroid Hormones Maintain the Stress-Induced Acetylcholine Release in the Hippocampus: Simultaneous Measurements of the Extracellular Acetylcholine and Serum Corticosterone Levels in the Same Subjects.
D. Mitsushima, K. Takase, T. Funabashi, and F. Kimura (2008)
Endocrinology 149, 802-811
   Abstract »    Full Text »    PDF »
Cell-Type Specific Modulation of Intrinsic Firing Properties and Subthreshold Membrane Oscillations by the M(Kv7)-Current in Neurons of the Entorhinal Cortex.
M. Yoshida and A. Alonso (2007)
J Neurophysiol 98, 2779-2794
   Abstract »    Full Text »    PDF »
Synaptic Plasticity (and the Lack Thereof) in Hippocampal CA2 Neurons.
M. Zhao, Y.-S. Choi, K. Obrietan, and S. M. Dudek (2007)
J. Neurosci. 27, 12025-12032
   Abstract »    Full Text »    PDF »
Multiple Gq-Coupled Receptors Converge on a Common Protein Synthesis-Dependent Long-Term Depression That Is Affected in Fragile X Syndrome Mental Retardation.
L. J. Volk, B. E. Pfeiffer, J. R. Gibson, and K. M. Huber (2007)
J. Neurosci. 27, 11624-11634
   Abstract »    Full Text »    PDF »
Muscarinic Receptor Activation Modulates Granule Cell Excitability and Potentiates Inhibition onto Mitral Cells in the Rat Olfactory Bulb.
R. T. Pressler, T. Inoue, and B. W. Strowbridge (2007)
J. Neurosci. 27, 10969-10981
   Abstract »    Full Text »    PDF »
Coincident Glutamatergic and Cholinergic Inputs Transiently Depress Glutamate Release at Rat Schaffer Collateral Synapses.
K. E. Gipson and M. F. Yeckel (2007)
J Neurophysiol 97, 4108-4119
   Abstract »    Full Text »    PDF »
Inhibition of Kainate Receptors Reduces the Frequency of Hippocampal Theta Oscillations.
J. R. Huxter, L. E. Zinyuk, E. v. L. Roloff, V. R. J. Clarke, N. P. Dolman, J. C. A. More, D. E. Jane, G. L. Collingridge, and R. U. Muller (2007)
J. Neurosci. 27, 2212-2223
   Abstract »    Full Text »    PDF »
Cholinergic modulation of hippocampal cells and circuits.
S. R. Cobb and C. H. Davies (2005)
J. Physiol. 562, 81-88
   Abstract »    Full Text »    PDF »
Metabotropic Regulation of Intrinsic Excitability by Synaptic Activation of Kainate Receptors.
Z. Melyan, B. Lancaster, and H. V. Wheal (2004)
J. Neurosci. 24, 4530-4534
   Abstract »    Full Text »    PDF »
KCNQ/M Channels Control Spike Afterdepolarization and Burst Generation in Hippocampal Neurons.
C. Yue and Y. Yaari (2004)
J. Neurosci. 24, 4614-4624
   Abstract »    Full Text »    PDF »
Somatic action potentials are sufficient for late-phase LTP-related cell signaling.
S. M. Dudek and R. D. Fields (2002)
PNAS 99, 3962-3967
   Abstract »    Full Text »    PDF »
Functional Specificity of Galpha q and Galpha 11 in the Cholinergic and Glutamatergic Modulation of Potassium Currents and Excitability in Hippocampal Neurons.
M. Krause, S. Offermanns, M. Stocker, and P. Pedarzani (2002)
J. Neurosci. 22, 666-673
   Abstract »    Full Text »    PDF »
Increased Excitability of Aged Rabbit CA1 Neurons after Trace Eyeblink Conditioning.
J. R. Moyer Jr, J. M. Power, L. T. Thompson, and J. F. Disterhoft (2000)
J. Neurosci. 20, 5476-5482
   Abstract »    Full Text »    PDF »
A Model for Pleiotropic Muscarinic Potentiation of Fast Synaptic Transmission.
H. Schobesberger, D. W. Wheeler, and J. P. Horn (2000)
J Neurophysiol 83, 1912-1923
   Abstract »    Full Text »    PDF »
The M1 Muscarinic Agonist CI-1017 Facilitates Trace Eyeblink Conditioning in Aging Rabbits and Increases the Excitability of CA1 Pyramidal Neurons.
C. Weiss, A. R. Preston, M. M. Oh, R. D. Schwarz, D. Welty, and J. F. Disterhoft (2000)
J. Neurosci. 20, 783-790
   Abstract »    Full Text »    PDF »
Long-Lasting Increase in Cellular Excitability Associated With the Priming of LTP Induction in Rat Hippocampus.
A. S. Cohen, C. M. Coussens, C. R. Raymond, and W. C. Abraham (1999)
J Neurophysiol 82, 3139-3148
   Abstract »    Full Text »    PDF »
Muscarinic Receptor Activity Induces an Afterdepolarization in a Subpopulation of Hippocampal CA1 Interneurons.
A. R. McQuiston and D. V. Madison (1999)
J. Neurosci. 19, 5703-5710
   Abstract »    Full Text »    PDF »
Metrifonate Increases Neuronal Excitability in CA1 Pyramidal Neurons from Both Young and Aging Rabbit Hippocampus.
M. M. Oh, J. M. Power, L. T. Thompson, P. L. Moriearty, and J. F. Disterhoft (1999)
J. Neurosci. 19, 1814-1823
   Abstract »    Full Text »    PDF »
Ionic Mechanisms of Action of Neurotensin in Acutely Dissociated Neurons From the Diagonal Band of Broca of the Rat.
B. S. Jassar, K. H. Harris, P. M. Ostashewski, and J. H. Jhamandas (1999)
J Neurophysiol 81, 234-246
   Abstract »    Full Text »    PDF »
Synaptic Potentials Mediated via alpha -Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors in Rat Hippocampal Interneurons.
C. J. Frazier, A. V. Buhler, J. L. Weiner, and T. V. Dunwiddie (1998)
J. Neurosci. 18, 8228-8235
   Abstract »    Full Text »    PDF »
Prenatal Dietary Choline Supplementation Decreases the Threshold for Induction of Long-Term Potentiation in Young Adult Rats.
G. K. Pyapali, D. A. Turner, C. L. Williams, W. H. Meck, and H. S. Swartzwelder (1998)
J Neurophysiol 79, 1790-1796
   Abstract »    Full Text »    PDF »
Transient Suppression of GABAA-Receptor-Mediated IPSPs After Epileptiform Burst Discharges in CA1 Pyramidal Cells.
F.E.N. L. Beau and B. E. Alger (1998)
J Neurophysiol 79, 659-669
   Abstract »    Full Text »    PDF »
Kinetics of Muscarinic Reduction of IsAHP in Hippocampal Neurons: Effects of Acetylcholinesterase Inhibitors.
Y. Zhang, P. L. Carlen, and L. Zhang (1997)
J Neurophysiol 78, 2999-3007
   Abstract »    Full Text »    PDF »
Trace Eyeblink Conditioning Increases CA1 Excitability in a Transient and Learning-Specific Manner.
J. R. Moyer Jr., L. T. Thompson, and J. F. Disterhoft (1996)
J. Neurosci. 16, 5536-5546
   Abstract »    Full Text »    PDF »
Somatostatin augments the M-current in hippocampal neurons.
S. Moore, S. Madamba, M Joels, and G. Siggins (1988)
Science 239, 278-280
   Abstract »    PDF »
Cellular mechanisms of epilepsy: a status report.
M. Dichter and G. Ayala (1987)
Science 237, 157-164
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)