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Science 23 September 1983:
Vol. 221. no. 4617, pp. 1292 - 1294
DOI: 10.1126/science.6577602
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Articles

Science, Vol 221, Issue 4617, 1292-1294
Copyright © 1983 by American Association for the Advancement of Science

articles

Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy

KJ Ibbotson, SM D'Souza, KW Ng, CK Osborne, M Niall, TJ Martin, and GR Mundy

Evidence is presented that a tumor-derived transforming growth factor is responsible for stimulating bone resorption and causing hypercalcemia in an animal tumor model of the hypercalcemia of malignancy. Both conditioned medium harvested from cultured tumor cells and tumor extracts of the transplantable rat Leydig cell tumor associated with hypercalcemia contained a macromolecular bone resorbing factor with the chemical characteristics of a tumor-derived transforming growth factor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The management of bone metastases: orthopaedic procedures.
J. Chalmers (1987)
Palliative Medicine 1, 121-127
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Hypercalcemia in the Critically Ill Patient.
C. Reasner and G. R. Mundy (1986)
J Intensive Care Med 1, 319-328
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Stimulation of bone resorption in vitro by synthetic transforming growth factor-alpha.
K. Ibbotson, D. Twardzik, S. D'Souza, W. Hargreaves, G. Todaro, and G. Mundy (1985)
Science 228, 1007-1009
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