Science 23 September 1983: Vol. 221. no. 4617, pp. 1285 - 1288 DOI: 10.1126/science.6137059

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Articles

Concise Review: Clinical Relevance of Drug Drug and Herb Drug Interactions Mediated by the ABC Transporter ABCB1 (MDR1, P-glycoprotein).

S. Marchetti, R. Mazzanti, J. H. Beijnen, and J. H. M. Schellens (2007)
Oncologist 12, 927-941
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Molecular Pharmacokinetics of Catharanthus (Vinca) Alkaloids.

D. Leveque and F. Jehl (2007)
J. Clin. Pharmacol. 47, 579-588
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P-Glycoprotein-Independent Apoptosis Induction by a Novel Synthetic Compound, MMPT [5-[(4-Methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone].

F. Teraishi, S. Wu, J. Sasaki, L. Zhang, H.-B. Zhu, J. J. Davis, and B. Fang (2005)
J. Pharmacol. Exp. Ther. 314, 355-362
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Gene Expression Analysis of Tumor Spheroids Reveals a Role for Suppressed DNA Mismatch Repair in Multicellular Resistance to Alkylating Agents.

G. Francia, S. Man, B. Teicher, L. Grasso, and R. S. Kerbel (2004)
Mol. Cell. Biol. 24, 6837-6849
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Intestinal P Glycoprotein Acts as a Natural Defense Mechanism against Listeria monocytogenes.

B. L. Neudeck, J. M. Loeb, N. G. Faith, and C. J. Czuprynski (2004)
Infect. Immun. 72, 3849-3854
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Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.

T.-L. Wang, L. A. Diaz Jr., K. Romans, A. Bardelli, S. Saha, G. Galizia, M. Choti, R. Donehower, G. Parmigiani, I.-M. Shih, et al. (2004)
PNAS 101, 3089-3094
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Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro.

S. K. Green, G. Francia, C. Isidoro, and R. S. Kerbel (2004)
Mol. Cancer Ther. 3, 149-159
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Multidrug-resistant Cancer Cells Facilitate E1-independent Adenoviral Replication: Impact for Cancer Gene Therapy.

P. S. Holm, H. Lage, S. Bergmann, K. Jurchott, G. Glockzin, A. Bernshausen, K. Mantwill, A. Ladhoff, A. Wichert, J. S. Mymryk, et al. (2004)
Cancer Res. 64, 322-328
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Subcellular Localization and Activity of Multidrug Resistance Proteins.

A. Rajagopal and S. M. Simon (2003)
Mol. Biol. Cell 14, 3389-3399
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Increased Penetration of Paclitaxel into the Brain by Inhibition of P-Glycoprotein.

E. M. Kemper, A. E. van Zandbergen, C. Cleypool, H. A. Mos, W. Boogerd, J. H. Beijnen, and O. van Tellingen (2003)
Clin. Cancer Res. 9, 2849-2855
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Apoptotic Susceptibility of Cancer Cells Selected for Camptothecin Resistance: Gene Expression Profiling, Functional Analysis, and Molecular Interaction Mapping.

W. C. Reinhold, H. Kouros-Mehr, K. W. Kohn, A. K. Maunakea, S. Lababidi, A. Roschke, K. Stover, J. Alexander, P. Pantazis, L. Miller, et al. (2003)
Cancer Res. 63, 1000-1011
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Effects of the Flavonoids Biochanin A, Morin, Phloretin, and Silymarin on P-Glycoprotein-Mediated Transport.

S. Zhang and M. E. Morris (2003)
J. Pharmacol. Exp. Ther. 304, 1258-1267
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Association of the P-Glycoprotein Transporter MDR1C3435T Polymorphism with the Susceptibility to Renal Epithelial Tumors.

M. Siegsmund, U. Brinkmann, E. Schaffeler, G. Weirich, M. Schwab, M. Eichelbaum, P. Fritz, O. Burk, J. Decker, P. Alken, et al. (2002)
J. Am. Soc. Nephrol. 13, 1847-1854
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Autocrine Production of Interleukin 6 Causes Multidrug Resistance in Breast Cancer Cells.

D. Conze, L. Weiss, P. S. Regen, A. Bhushan, D. Weaver, P. Johnson, and M. Rincon (2001)
Cancer Res. 61, 8851-8858
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MDR1 Gene Overexpression and Altered Degree of Methylation at the Promoter Region in Bladder Cancer during Chemotherapeutic Treatment.

Y. Tada, M. Wada, K. Kuroiwa, N. Kinugawa, T. Harada, J. Nagayama, M. Nakagawa, S. Naito, and M. Kuwano (2000)
Clin. Cancer Res. 6, 4618-4627
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Communication between Multiple Drug Binding Sites on P-glycoprotein.

C. Martin, G. Berridge, C. F. Higgins, P. Mistry, P. Charlton, and R. Callaghan (2000)
Mol. Pharmacol. 58, 624-632
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Energy Metabolism of Human LoVo Colon Carcinoma Cells: Correlation to Drug Resistance and Influence of Lonidamine.

M. Fanciulli, T. Bruno, A. Giovannelli, F. P. Gentile, M. Di Padova, O. Rubiu, and A. Floridi (2000)
Clin. Cancer Res. 6, 1590-1597
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In Situ Biochemical Demonstration that P-Glycoprotein Is a Drug Efflux Pump with Broad Specificity.

Y. Chen and S. M. Simon (2000)
J. Cell Biol. 148, 863-870
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Genetic and Epigenetic Factors in Anticancer Drug Resistance.

R. H. Shoemaker (2000)
J Natl Cancer Inst 92, 4-5
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Use of a Peptide Mimotope to Guide the Humanization of MRK-16, an Anti-P-glycoprotein Monoclonal Antibody.

Y. Tang, G. Beuerlein, G. Pecht, T. Chilton, W. D. Huse, and J. D. Watkins (1999)
J. Biol. Chem. 274, 27371-27378
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Mechanisms of Action of and Resistance to Antitubulin Agents: Microtubule Dynamics, Drug Transport, and Cell Death.

C. Dumontet and B. I. Sikic (1999)
J. Clin. Oncol. 17, 1061
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Hypomethylation Status of CpG Sites at the Promoter Region and Overexpression of the Human MDR1 Gene in Acute Myeloid Leukemias.

M. Nakayama, M. Wada, T. Harada, J. Nagayama, H. Kusaba, K. Ohshima, M. Kozuru, H. Komatsu, R. Ueda, and M. Kuwano (1998)
Blood 92, 4296-4307
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QacR Is a Repressor Protein That Regulates Expression of the Staphylococcus aureus Multidrug Efflux Pump QacA.

S. Grkovic, M. H. Brown, N. J. Roberts, I. T. Paulsen, and R. A. Skurray (1998)
J. Biol. Chem. 273, 18665-18673
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Resistance to Diverse Drugs and Ultraviolet Light Conferred by Overexpression of a Novel Human 26 S Proteasome Subunit.

V. Spataro, T. Toda, R. Craig, M. Seeger, W. Dubiel, A. L. Harris, and C. Norbury (1997)
J. Biol. Chem. 272, 30470-30475
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A Single Chain Fv Fragment of P-glycoprotein-specific Monoclonal Antibody C219. DESIGN, EXPRESSION, AND CRYSTAL STRUCTURE AT 2.4 A RESOLUTION.

F. J. Hoedemaeker, T. Signorelli, K. Johns, D. A. Kuntz, and D. R. Rose (1997)
J. Biol. Chem. 272, 29784-29789
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What does Multidrug Resistance (MDR) Expression Mean in the Clinic?.

C. Duhem, F. Ries, and M. Dicato (1996)
Oncologist 1, 151-158
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Experimental Models for the Study of Drug Resistance in Osteosarcoma: P-Glycoprotein-Positive, Murine Osteosarcoma Cell Lines.

H. TAKESHITA, M. C. GEBHARDT, D. S. SPRINGFIELD, K. KUSUZAKI, and H. J. MANKIN (1996)
J. Bone Joint Surg. Am. 78, 366-75
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Role of the glutathione redox cycle in acquired and de novo multidrug resistance.

R. Kramer, J Zakher, and G Kim (1988)
Science 241, 694-697
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Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.

D. Shen, A Fojo, J. Chin, I. Roninson, N Richert, I Pastan, and M. Gottesman (1986)
Science 232, 643-645
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Transport Activity and Surface Expression of the Na+-Ca2+ Exchanger NCX1 Are Inhibited by the Immunosuppressive Agent Cyclosporin A and by the Nonimmunosuppressive Agent PSC833.

C. Kimchi-Sarfaty, J. Kasir, S. V. Ambudkar, and H. Rahamimoff (2002)
J. Biol. Chem. 277, 2505-2510
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Origin of multidrug resistance in cells with and without multidrug resistance genes: Chromosome reassortments catalyzed by aneuploidy.

P. Duesberg, R. Stindl, and R. Hehlmann (2001)
PNAS 98, 11283-11288
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