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Science 23 September 1983:
Vol. 221. no. 4617, pp. 1283 - 1285
DOI: 10.1126/science.6612342
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Articles

Science, Vol 221, Issue 4617, 1283-1285
Copyright © 1983 by American Association for the Advancement of Science

articles

Oxygen tension regulates the expression of angiogenesis factor by macrophages

DR Knighton, TK Hunt, H Scheuenstuhl, BJ Halliday, Z Werb, and MJ Banda

When cultured in a hypoxic environment similar to that found in the center of a wound, macrophages secreted active angiogenesis factor into the medium. Under conditions similar to those of well-oxygenated tissue, macrophages did not secrete active angiogenesis factor. Macrophages that secreted the factor at hypoxic conditions stopped secreting it when returned to room air. Thus the control of angiogenesis in wound healing may be the result of macrophages responding to tissue oxygen tension without the necessity of interacting with other cell types or biochemical signals.


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