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Science 23 September 1983:
Vol. 221. no. 4617, pp. 1264 - 1266
DOI: 10.1126/science.6604315
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Articles

Science, Vol 221, Issue 4617, 1264-1266
Copyright © 1983 by American Association for the Advancement of Science

articles

Imaging dopamine receptors in the human brain by positron tomography

HN Wagner Jr, HD Burns, RF Dannals, DF Wong, B Langstrom, T Duelfer, JJ Frost, HT Ravert, JM Links, SB Rosenbloom, SE Lukas, AV Kramer, and MJ Kuhar

Neurotransmitter receptors may be involved in a number of neuropsychiatric disease states. The ligand 3-N-[11C]methylspiperone, which preferentially binds to dopamine receptors in vivo, was used to image the receptors by positron emission tomography scanning in baboons and in humans. This technique holds promise for noninvasive clinical studies of dopamine receptors in humans.


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