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Science 23 September 1983: Vol. 221. no. 4617, pp. 1256 - 1264 DOI: 10.1126/science.6351251
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Articles
Science, Vol 221, Issue 4617, 1256-1264
Copyright © 1983 by American Association for the Advancement of Science
Dietary carcinogens and anticarcinogens: Oxygen radicals and degenerative diseases
BN Ames
The human diet contains a great variety of natural mutagens and carcinogens, as well as many natural antimutagens and anticarcinogens. Many of these mutagens and carcinogens may act through the generation of oxygen radicals. Oxygen radicals may also play a major role as endogenous initiators of degenerative processes, such as DNA damage and mutation (and promotion), that may be related to cancer, heart disease, and aging. Dietary intake of natural antioxidants could be an important aspect of the body's defense mechanism against these agents. Many antioxidants are being identified as anticarcinogens. Characterizing and optimizing such defense systems may be an important part of a strategy of minimizing cancer and other age-related diseases.
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| Full Text »
| PDF »
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| Full Text »
| PDF »
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| Full Text »
| PDF »
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| Full Text »
| PDF »
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| Full Text »
| PDF »
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| Abstract »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- K. Asagoshi, H. Terato, Y. Ohyama, and H. Ide (2002)
J. Biol. Chem.
277, 14589-14597
| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- W. Adam, M. A. Arnold, W. M. Nau, U. Pischel, and C. R. Saha-Moller (2001)
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| Abstract »
| Full Text »
| PDF »
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- Y. Gu and A-L. Lu (2001)
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- D. T. Odom, E. A. Dill, and J. K. Barton (2001)
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| Abstract »
| Full Text »
| PDF »
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- M. McMahon, K. Itoh, M. Yamamoto, S. A. Chanas, C. J. Henderson, L. I. McLellan, C. R. Wolf, C. Cavin, and J. D. Hayes (2001)
Cancer Res.
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| Abstract »
| Full Text »
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- C. R. Wolf (2001)
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98, 2941-2943
| Full Text »
| PDF »
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- K. Mitrunen, N. Jourenkova, V. Kataja, M. Eskelinen, V.-M. Kosma, S. Benhamou, H. Vainio, M. Uusitupa, and A. Hirvonen (2001)
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| Abstract »
| Full Text »
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- K. Fujikawa, H. Kamiya, H. Yakushiji, Y. Nakabeppu, and H. Kasai (2001)
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29, 449-454
| Abstract »
| Full Text »
| PDF »
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- T.-G. WANG, Y. GOTOH, M. H. JENNINGS, C. A. RHOADS, and T. Y. AW (2000)
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14, 1567-1576
| Abstract »
| Full Text »
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Arch Dermatol
136, 989-994
| Abstract »
| Full Text »
| PDF »
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- P. A. Thompson and C. Ambrosone (2000)
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2000, 125-134
| Abstract »
| Full Text »
| PDF »
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- V. Duarte, D. Gasparutto, M. Jaquinod, and J. Cadet (2000)
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28, 1555-1563
| Abstract »
| Full Text »
| PDF »
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- H. Kamiya and H. Kasai (2000)
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28, 1640-1646
| Abstract »
| Full Text »
| PDF »
- Glutathione S-Transferase in Mucus of Rat Small Intestine.
- P. S. Samiec, L. J. Dahm, and D. P. Jones (2000)
Toxicol. Sci.
54, 52-59
| Abstract »
| Full Text »
| PDF »
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- T. Najrana, Y. Saito, F. Uraki, K. Kubo, and K. Yamamoto (2000)
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15, 121-125
| Abstract »
| Full Text »
| PDF »
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- G. Bentham, A. M. Wolfreys, Y. Liu, G. Cortopassi, M. H.L. Green, C. F. Arlett, and J. Cole (1999)
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14, 527-532
| Abstract »
| Full Text »
| PDF »
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- T. Y. Aw (1999)
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70, 557-565
| Abstract »
| Full Text »
| PDF »
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- T. Tanaka, K. Kawabata, M. Kakumoto, H. Makita, J. Ushida, S. Honjo, A. Hara, H. Tsuda, and H. Mori (1999)
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| Abstract »
| Full Text »
| PDF »
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- K. Fujikawa, H. Kamiya, H. Yakushiji, Y. Fujii, Y. Nakabeppu, and H. Kasai (1999)
J. Biol. Chem.
274, 18201-18205
| Abstract »
| Full Text »
| PDF »
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- T. Minamoto, M. Mai, and Z.'e. Ronai (1999)
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20, 519-527
| Abstract »
| Full Text »
| PDF »
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Cancer Res.
59, 602-606
| Abstract »
| Full Text »
| PDF »
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- C. B. Ambrosone, B. F. Coles, J. L. Freudenheim, and P. G. Shields (1999)
J. Nutr.
129, 565
| Abstract »
| Full Text »
| PDF »
- Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.
- K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, J. D. Engel, and M. Yamamoto (1999)
Genes & Dev.
13, 76-86
| Abstract »
| Full Text »
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- M. Kobayashi, Y. Ohara-Nemoto, M. Kaneko, H. Hayakawa, M. Sekiguchi, and K. Yamamoto (1998)
J. Biol. Chem.
273, 26394-26399
| Abstract »
| Full Text »
| PDF »
- Oxidative DNA damage measured in human lymphocytes: large differences between sexes and between countries, and correlations with heart disease mortality rates.
- A. R. Collins, C. M. Gedik, B. Olmedilla, S. Southon, and M. Bellizzi (1998)
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12, 1397-1400
| Abstract »
| Full Text »
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- J. D. Morrow, J. Scruggs, Y. Chen, W. E. Zackert, and L. J. R. II (1998)
J. Lipid Res.
39, 1589-1593
| Abstract »
| Full Text »
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- M. Inoue, H. Kamiya, K. Fujikawa, Y. Ootsuyama, N. Murata-Kamiya, T. Osaki, K. Yasumoto, and H. Kasai (1998)
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273, 11069-11074
| Abstract »
| Full Text »
| PDF »
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- C. V. Ramana, I. Boldogh, T. Izumi, and S. Mitra (1998)
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| Abstract »
| Full Text »
| PDF »
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- T. S. Legrand and T. Y. Aw (1998)
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| Abstract »
| Full Text »
| PDF »
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- I Shimizu, M Yasuda, Y Mizobuchi, Y-R Ma, F Liu, M Shiba, T Horie, and S Ito (1998)
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| Abstract »
| Full Text »
| PDF »
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- B. Hang, B. Singer, G. P. Margison, and R. H. Elder (1997)
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| Abstract »
| Full Text »
| PDF »
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- W. Che, M. Asahi, M. Takahashi, H. Kaneto, A. Okado, S. Higashiyama, and N. Taniguchi (1997)
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272, 18453-18459
| Abstract »
| Full Text »
| PDF »
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- P. Slovic, T. Malmfors, C. Mertz, N. Neil, and I. F. Purchase (1997)
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| Abstract »
| PDF »
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- R. Roy, A. Kumar, J. C. Lee, and S. Mitra (1996)
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271, 23690-23697
| Abstract »
| Full Text »
| PDF »
- Nonenzymatic Free Radical-catalyzed Generation of Thromboxane-like Compounds (Isothromboxanes) in Vivo.
- J. D. Morrow, J. A. Awad, A. Wu, W. E. Zackert, V. C. Daniel, and L. J. Roberts II (1996)
J. Biol. Chem.
271, 23185-23190
| Abstract »
| Full Text »
| PDF »
- Identification of the Major Urinary Metabolite of the F2-isoprostane 8-Iso-prostaglandin F2alpha in Humans.
- L. J. Roberts II, K. P. Moore, W. E. Zackert, J. A. Oates, and J. D. Morrow (1996)
J. Biol. Chem.
271, 20617-20620
| Abstract »
| Full Text »
| PDF »
- Manganese Superoxide Dismutase Modulates Interleukin-1alpha Levels in HT-1080 Fibrosarcoma Cells.
- J. A. Melendez and K. J.A. Davies (1996)
J. Biol. Chem.
271, 18898-18903
| Abstract »
| Full Text »
| PDF »
- Failure to Detect Free Radicals in the Isolated Perfused Rat Heart.
- L. H. Piette, J. J. McNamara, S. Premaratne, and W. Zhang (1996)
Angiology
47, 1-7
| Abstract »
| PDF »
- The discipline of epidemiology.
- W Willett, S Greenland, B MacMahon, D Trichopoulos, K Rothman, D Thomas, M Thun, and N Weiss (1995)
Science
269, 1325-1326
| PDF »
- Simultaneous Overexpression of Copper- and Zinc-containing Superoxide Dismutase and Catalase Retards Age-related Oxidative Damage and Increases Metabolic Potential in Drosophila melanogaster.
- R. S. Sohal, A. Agarwal, S. Agarwal, and W. C. Orr (1995)
J. Biol. Chem.
270, 15671-15674
| Abstract »
| Full Text »
| PDF »
- Bionutrition and Oral Cancer in Humans.
- C.O. Enwonwu and V.I. Meeks (1995)
Critical Reviews in Oral Biology & Medicine
6, 5-17
| Abstract »
| Full Text »
| PDF »
- Cell cycle control and cancer.
- L. Hartwell and M. Kastan (1994)
Science
266, 1821-1828
| Abstract »
| PDF »
- Eugenol Triggers Different Pathobiological Effects on Human Oral Mucosal Fibroblasts 1.
- J.H. Jeng, L.J. Hahn, E. Lu, Y. Wang, and M.Y.P. Kuo (1994)
Journal of Dental Research
73, 1050-1055
| Abstract »
| PDF »
- Vitamins Regulate Gene Expression and Induce Differentiation and Growth Inhibition in Cancer Cells: Their Relevance in Cancer Prevention.
- K. N. Prasad, J. Edwards-Prasad, S. Kumar, and A. Meyers (1993)
Arch Otolaryngol Head Neck Surg
119, 1133-1140
| Abstract »
| PDF »
- How Much Cancer Is Occupationally Derived.
- F.J.C. Roe (1993)
Indoor and Built Environment
2, 38-42
| PDF »
- Multistep carcinogenesis: a 1992 perspective.
- T Sugimura (1992)
Science
258, 603-607
| Abstract »
| PDF »
- Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III.
- C. Kuo, D. McRee, C. Fisher, S. O'Handley, R. Cunningham, and J. Tainer (1992)
Science
258, 434-440
| Abstract »
| PDF »
- Review : Acetaldehyde and Formaldehyde: Is There a Cancer Risk for Man?.
- F.J.C. Roe and D. Wood (1992)
Indoor and Built Environment
1, 8-15
| Abstract »
| PDF »
- Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation.
- G Storz, L. Tartaglia, and B. Ames (1990)
Science
248, 189-194
| Abstract »
| PDF »
- Yes, But Is It a Human Carcinogen?.
- A. Furst (1990)
International Journal of Toxicology
9, 1-18
| PDF »
- Cultured Cells as a Screen for Novel Treatments of Alzheimer's Disease.
- B. A. Malow, A. C. Baker, and J. P. Blass (1989)
Arch Neurol
46, 1201-1203
| Abstract »
| PDF »
- Controversies over Pesticides: The Lessons for Public Health.
- J. F. Copplestone (1989)
Asia Pac J Public Health
3, 165-170
| Abstract »
| PDF »
- Cigarette Smoking and Exposure to Passive Smoke Are Risk Factors for Cervical Cancer.
- M. L. Slattery, L. M. Robison, K. L. Schuman, T. K. French, T. M. Abbott, J. C. Overall Jr, and J. W. Gardner (1989)
JAMA
261, 1593-1598
| Abstract »
| PDF »
- The Role of Chemicals in the Etiology of Diabetes Mellitus.
- G. L. Wilson and S. P. LeDoux (1989)
Toxicol Pathol
17, 357-363
| Abstract »
| PDF »
|
|