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Science 16 September 1983:
Vol. 221. no. 4616, pp. 1201 - 1203
DOI: 10.1126/science.6612335
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Articles

Science, Vol 221, Issue 4616, 1201-1203
Copyright © 1983 by American Association for the Advancement of Science

articles

Membrane changes in a single photoreceptor cause associative learning in Hermissenda

J Farley, WG Richards, LJ Ling, E Liman, and DL Alkon

Single type B photoreceptors in intact, restrained Hermissenda were impaled with a microelectrode and exposed to either paired or unpaired presentations of light and depolarizing current to simulate natural stimulus effects during conditioning with light and rotation. Paired, but not unpaired, stimulus presentations produced cumulative depolarization and increased input resistance in type B cells. These membrane changes are similar to those observed after pairings of light and rotation are administered to either intact animals or isolated nervous systems or when light is paired with electrical stimulation of the vestibular system in isolated nervous systems. One and two days after treatment, pairing- and light-specific suppression of phototactic behavior was observed in recovered animals. These findings indicate that the membrane changes of type B cells produced by pairing light with current injections cause acquisition of the learned behavior.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bryostatin Enhancement of Memory in Hermissenda.
A. M. Kuzirian, H. T. Epstein, C. J. Gagliardi, T. J. Nelson, M. Sakakibara, C. Taylor, A. B. Scioletti, and D. L. Alkon (2006)
Biol. Bull. 210, 201-214
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Perturbation of the activity of a single identified neuron affects long-term memory formation in a molluscan semi-intact preparation.
M. R. Lowe and G. E. Spencer (2006)
J. Exp. Biol. 209, 711-721
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Involvement of the Ryanodine Receptor in Morphologic Modification of Hermissenda Type B Photoreceptors After In Vitro Conditioning.
R. Kawai, T. Horikoshi, and M. Sakakibara (2004)
J Neurophysiol 91, 728-735
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Behavioral and Neural Bases of Noncoincidence Learning in Hermissenda.
G. Britton and J. Farley (1999)
J. Neurosci. 19, 9126-9132
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Protein synthesis-dependent memory and neuronal enhancement in Hermissenda are contingent on parameters of training and retention..
R R Ramirez, C C Gandhi, I A Muzzio, and L D Matzel (1998)
Learn. Mem. 4, 462-477
   Abstract »    PDF »
Ionic Basis of Learning-Correlated Excitability Changes in Hermissenda Type A Photoreceptors.
J. Farley and Y. Han (1997)
J Neurophysiol 77, 1861-1888
   Abstract »    Full Text »    PDF »
Higher-order associative processing in Hermissenda suggests multiple sites of neuronal modulation..
R F Rogers and L D Matzel (1996)
Learn. Mem. 2, 279-298
   Abstract »    PDF »
Calcium-mediated reduction of ionic currents: a biophysical memory trace.
D. Alkon (1984)
Science 226, 1037-1045
   Abstract »    PDF »
Ca2+-dependent protein kinase injection in a photoreceptor mimics biophysical effects of associative learning.
J Acosta-Urquidi, D. Alkon, and J. Neary (1984)
Science 224, 1254-1257
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