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Science 16 September 1983:
Vol. 221. no. 4616, pp. 1198 - 1201
DOI: 10.1126/science.6310750
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Articles

Science, Vol 221, Issue 4616, 1198-1201
Copyright © 1983 by American Association for the Advancement of Science

articles

An opiate binding site in the rat brain is highly selective for 4,5-epoxymorphinans

J Grevel and W Sadee

In vitro binding studies have demonstrated the existence of multiple opiate receptor types. An additional site in the rat brain (termed the lambda site) is distinct from the established types by its selectivity for 4,5-epoxymorphinans (such as naloxone and morphine). While the lambda site displays a high affinity for naloxone in vivo and in vitro in fresh brain membrane homogenates, these sites rapidly convert in vitro to a state of low affinity. The regional distribution of the lambda site in the brain is strikingly different from that of the classic opiate receptor types.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)