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Science 16 September 1983:
Vol. 221. no. 4616, pp. 1183 - 1185
DOI: 10.1126/science.6612332
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Articles

Science, Vol 221, Issue 4616, 1183-1185
Copyright © 1983 by American Association for the Advancement of Science

articles

Altered activity patterns during development reduce neural tuning

DH Sanes and M Constantine-Paton

Neonatal mice were reared in an acoustic environment that repetitively entrained activity in a large proportion of primary auditory afferents during the period when the frequency tuning of auditory neurons normally develops. The tuning curves obtained from these mice were significantly broader than those of normally reared mice of the same age. This suggests that the normal frequency tuning of neurons was prevented or delayed by synchronizing the pattern of activity imposed on the auditory pathway.


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