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Science 16 September 1983:
Vol. 221. no. 4616, pp. 1181 - 1183
DOI: 10.1126/science.6310748
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Articles

Science, Vol 221, Issue 4616, 1181-1183
Copyright © 1983 by American Association for the Advancement of Science

articles

1,25-dihydroxyvitamin D3 receptors in human leukocytes

DM Provvedini, CD Tsoukas, LJ Deftos, and SC Manolagas

A 1,25-dihydroxyvitamin D3 receptor macromolecule was detected in peripheral mononuclear leukocytes from normal humans. This macromolecule was found to be present in monocytes but absent from normal resting peripheral B and T lymphocytes. However, it was present in established lines of malignant B, T, and non-B, non-T human lymphocytes, as well as in T and B lymphocytes obtained from normal humans and activated in vitro.


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Differential Regulation of Gene Transcription in Subpopulations of Human B Lymphocytes by Vitamin D3.
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1,25-Dihydroxyvitamin D3 Is a Positive Regulator for the Two Anti-Encephalitogenic Cytokines TGF-{beta}1 and IL-4.
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Accelerated Bone Formation Causing Profound Hypocalcemia in Acute Leukemia.
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Ann Intern Med 105, 375-378
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1,25-dihydroxyvitamin D3: a novel immunoregulatory hormone.
C. Tsoukas, D. Provvedini, and S. Manolagas (1984)
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The Vitamin D Endocrine System and the Hematolymphopoietic Tissue.
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