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Science 16 September 1983:
Vol. 221. no. 4616, pp. 1177 - 1179
DOI: 10.1126/science.6612330
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Articles
Science, Vol 221, Issue 4616, 1177-1179
Copyright © 1983 by American Association for the Advancement of Science
Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor
WG Robison Jr,
PF Kador,
and
JH Kinoshita
A twofold thickening of capillary basement membranes of rat retinas resulting from dietary galactose was prevented by sorbinil, an inhibitor of aldose reductase. Since the basement membrane thickening was ultrastructurally similar to that typical of diabetic retinopathy, it may indicate changes in vessel permeability and susceptibility to hemorrhage. Galactosemic rats should be useful models for studying basement membrane-related complications of diabetes and for examining the potential biochemical regulation of basement membrane synthesis by aldose reductase inhibitors.
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