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Science 9 September 1983:
Vol. 221. no. 4615, pp. 1057 - 1059
DOI: 10.1126/science.6348948
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Articles

Science, Vol 221, Issue 4615, 1057-1059
Copyright © 1983 by American Association for the Advancement of Science

articles

A serological test for leprosy with a glycolipid specific for Mycobacterium leprae

DB Young and TM Buchanan

A phenolic glycolipid from Mycobacterium leprae was purified and used as antigen in an enzyme-linked immunosorbent assay. Antibodies directed against the lipid were seen in serums from leprosy patients but not in serums from uninfected controls or patients infected with other mycobacteria, including Mycobacterium tuberculosis. The antibody response distinguished between the Mycobacterium leprae lipid and the structurally related phenolic glycolipid from Mycobacterium kansasii. This assay has considerable potential as a specific serodiagnostic test for leprosy infection.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Selection of Antigens and Development of Prototype Tests for Point-of-Care Leprosy Diagnosis.
M. S. Duthie, G. C. Ireton, G. V. Kanaujia, W. Goto, H. Liang, A. Bhatia, J. M. Busceti, M. Macdonald, K. D. Neupane, C. Ranjit, et al. (2008)
Clin. Vaccine Immunol. 15, 1590-1597
   Abstract »    Full Text »    PDF »
Use of Protein Antigens for Early Serological Diagnosis of Leprosy.
M. S. Duthie, W. Goto, G. C. Ireton, S. T. Reece, L. P. V. Cardoso, C. M. T. Martelli, M. M. A. Stefani, M. Nakatani, R. C. de Jesus, E. M. Netto, et al. (2007)
Clin. Vaccine Immunol. 14, 1400-1408
   Abstract »    Full Text »    PDF »
Glycolipids of Mycobacterium tuberculosis Strain H37Rv Are Potential Serological Markers for Diagnosis of Active Tuberculosis.
R. P. Tiwari, D. Tiwari, S. K. Garg, R. Chandra, and P. S. Bisen (2005)
Clin. Vaccine Immunol. 12, 465-473
   Abstract »    Full Text »    PDF »


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