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Science 9 September 1983:
Vol. 221. no. 4615, pp. 1050 - 1052
DOI: 10.1126/science.6879204
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Articles

Science, Vol 221, Issue 4615, 1050-1052
Copyright © 1983 by American Association for the Advancement of Science

articles

Burst discharge in mammalian neuroendocrine cells involves an intrinsic regenerative mechanism

RD Andrew and FE Dudek

Intracellular recordings from mammalian neuroendocrine cells showed that steady, injected currents can modify and block periodic spike bursts previously associated with increased neurohormone release. Spike afterpotentials could sum to form plateau potentials, which generated bursts and did not depend on axonal conduction or chemical synapses. Therefore, bursting involves a spike-dependent, positive-feedback mechanism endogenous to single neuroendocrine cells.


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