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Science 9 September 1983:
Vol. 221. no. 4615, pp. 1013 - 1019
DOI: 10.1126/science.221.4615.1013
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Articles

Current Status of Asymmetric Synthesis

Harry S. Mosher 1 and James D. Morrison 2

1 Professor emeritus, Department of Chemistry, Stanford University, Stanford, California 94305
2 Professor, Department of Chemistry, University of New Hampshire, Durham 03824.

In the last 30 years the subject of asymmetric synthesis has grown from a little studied academic niche in organic chemistry to an intensely investigated field of commercial importance and heightened general interest. Impressive advances have been made in several areas, notably catalytic asymmetric homogeneous hydrogenation, catalytic asymmetric epoxidation of allyl alcohols and stereochemical control of carbon-carbon bond-forming reactions. Asymmetric synthesis must now be deliberately considered along with other available methods as a practical strategy for the synthesis of any chiral compound.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Theory and modeling of stereoselective organic reactions.
K. Houk, M. Paddon-Row, N. Rondan, Y. Wu, F. Brown, D. Spellmeyer, J. Metz, Y Li, and R. Loncharich (1986)
Science 231, 1108-1117
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