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Science 2 September 1983:
Vol. 221. no. 4614, pp. 969 - 971
DOI: 10.1126/science.6879197
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Articles

Science, Vol 221, Issue 4614, 969-971
Copyright © 1983 by American Association for the Advancement of Science

articles

Haloperidol-induced plasticity of axon terminals in rat substantia nigra

FM Benes, PA Paskevich, and VB Domesick

An electron micrographic morphometric analysis of nerve endings in substantia nigra of rats repeatedly treated with haloperidol was performed. Although most parameters showed no difference, drug-treated animals exhibited a significant shift in the distribution of relative numbers of axon terminals, suggesting neuroleptic-induced axon-collateral sprouting.


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