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Science 2 September 1983:
Vol. 221. no. 4614, pp. 964 - 966
DOI: 10.1126/science.6879195
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Articles

Science, Vol 221, Issue 4614, 964-966
Copyright © 1983 by American Association for the Advancement of Science

articles

Evidence for the recessive nature of cellular immortality

OM Pereira-Smith and Smith JR

Fusion of immortal cell lines with normal human fibroblasts or certain other immortal cell lines yields hybrids having limited division potential. Cellular immortality was found to be a recessive phenotype in hybrids. It was also found that at least two separate events in the normal cell genome can result in immortality. In fusions involving certain immortal parent cells, these events can be complemented to result in hybrids with finite division capacity.


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Induction of cellular senescence in immortalized cells by human chromosome 1.
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Existence of high abundance antiproliferative mRNA's in senescent human diploid fibroblasts.
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