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Science 2 September 1983:
Vol. 221. no. 4614, pp. 955 - 957
DOI: 10.1126/science.6879193
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Articles

Science, Vol 221, Issue 4614, 955-957
Copyright © 1983 by American Association for the Advancement of Science

articles

Human fetal muscle and cultured myotubes derived from it contain a fetal-specific myosin light chain

RC Strohman, J Micou-Eastwood, CA Glass, and R Matsuda

Human fetal muscles at ages 110, 125, and 132 days contain a fetal-specific myosin light chain. This light chain is absent in adult human muscle, copurifies with myosin, and is identified as a slow light chain because it reacts with purified antibody to chicken slow muscle light chains and does not react strongly with antibody to fast myosin light chains. This light chain is synthesized in cultures of fetal muscle along with normal myosin light chains. The presence of a fetal light chain in culture provides a marker for studies of human muscle disease in which it is important to know when or if the muscle makes a transition from embryonic or fetal expression to true adult phenotype.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene.
J. Khan, M. L. Bittner, L. H. Saal, U. Teichmann, D. O. Azorsa, G. C. Gooden, W. J. Pavan, J. M. Trent, and P. S. Meltzer (1999)
PNAS 96, 13264-13269
   Abstract »    Full Text »    PDF »
Adult fast myosin pattern and Ca2+-induced slow myosin pattern in primary skeletal muscle culture.
H.-P. Kubis, E.-A. Haller, P. Wetzel, and G. Gros (1997)
PNAS 94, 4205-4210
   Abstract »    Full Text »    PDF »


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