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Science 2 September 1983:
Vol. 221. no. 4614, pp. 953 - 955
DOI: 10.1126/science.6192500
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Articles

Science, Vol 221, Issue 4614, 953-955
Copyright © 1983 by American Association for the Advancement of Science

articles

Cell-to-cell transfer of interferon-induced antiproliferative activity

RE Lloyd, JE Blalock, and GJ Stanton

Interferon-treated cells rapidly and efficiently transferred the antiproliferative activity of interferon to untreated cells. This phenomenon was not due to the carry-over of interferon by the interferon-treated cells. Thus, to evoke an antiproliferative state, interferon did not directly contact each cell in a population. The results suggest a novel mechanism by which interferon may indirectly regulate cell growth, and suggests that cells other than those of the immune system may play a role in controlling tumor growth in tissue where cell-to-cell contact occurs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Expression Cloning of an Interferon-inducible 17-kDa Membrane Protein Implicated in the Control of Cell Growth.
G.čl. A. Deblandre, O. P. Marinx, S. S. Evans, S. Majjaj, O. Leo, D. Caput, G. A. Huez, and M. G. Wathelet (1995)
J. Biol. Chem. 270, 23860-23866
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Science. ISSN 0036-8075 (print), 1095-9203 (online)