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Science 26 August 1983:
Vol. 221. no. 4613, pp. 881 - 882
DOI: 10.1126/science.6879187
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Articles

Science, Vol 221, Issue 4613, 881-882
Copyright © 1983 by American Association for the Advancement of Science

articles

Otosclerotic lesions in the inbred LP/J mouse

RA Chole and KR Henry

Inbred LP/J mice develop abnormal bony lesions that are grossly and histologically similar to the lesions of human otosclerosis. This is the first known occurrence of spontaneous otosclerosis-like lesions in an animal. As in the human disease, these lesions impair audition by immobilizing the ossicles of the middle ear. The LP/J mouse may be an animal model for this common human disease.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)