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Science 26 August 1983:
Vol. 221. no. 4613, pp. 877 - 879
DOI: 10.1126/science.6136091
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Articles

Science, Vol 221, Issue 4613, 877-879
Copyright © 1983 by American Association for the Advancement of Science

articles

Neuropeptide Y distribution in the rat brain

YS Allen, TE Adrian, JM Allen, K Tatemoto, TJ Crow, Bloom SR, and JM Polak

A massive neuronal system was detected by immunocytochemistry and radioimmunoassay with antibodies to neuropeptide Y, the recently isolated peptide of the pancreatic polypeptide family. Immunoreactive cell bodies and fibers were most prevalent in cortical, limbic, and hypothalamic regions. Neuropeptide Y was extracted in concentrations higher than those of any other peptide hitherto discovered in the mammalian brain. Column chromatography of brain extracts and double immunostaining experiments indicate that neuropeptide Y is the endogenous brain peptide responsible for immunostaining of pancreatic polypeptide-like immunoreactivity in the mammalian brain.


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