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Science 26 August 1983:
Vol. 221. no. 4613, pp. 869 - 871
DOI: 10.1126/science.6879184
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Articles

Science, Vol 221, Issue 4613, 869-871
Copyright © 1983 by American Association for the Advancement of Science

articles

Angiotensin synthesis in the brain and increased turnover in hypertensive rats

D Ganten, K Hermann, C Bayer, T Unger, and RE Lang

The missing link in the evidence for an active endogenous renin angiotensin system in the brain has been the demonstration of local angiotensin synthesis in the central nervous system in vivo. In this report the extraction and characterization of angiotensin I and angiotensin II from the brain of rats is described. The accumulation of angiotensin I was enhanced in hypertensive rats when the conversion to angiotensin II was blocked in vivo by the converting enzyme inhibitor captopril.


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