Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 26 August 1983:
Vol. 221. no. 4613, pp. 869 - 871
DOI: 10.1126/science.6879184
Prev | Table of Contents | Next

Articles

Science, Vol 221, Issue 4613, 869-871
Copyright © 1983 by American Association for the Advancement of Science

articles

Angiotensin synthesis in the brain and increased turnover in hypertensive rats

D Ganten, K Hermann, C Bayer, T Unger, and RE Lang

The missing link in the evidence for an active endogenous renin angiotensin system in the brain has been the demonstration of local angiotensin synthesis in the central nervous system in vivo. In this report the extraction and characterization of angiotensin I and angiotensin II from the brain of rats is described. The accumulation of angiotensin I was enhanced in hypertensive rats when the conversion to angiotensin II was blocked in vivo by the converting enzyme inhibitor captopril.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Orally Active Aminopeptidase A Inhibitors Reduce Blood Pressure: A New Strategy for Treating Hypertension.
L. Bodineau, A. Frugiere, Y. Marc, N. Inguimbert, C. Fassot, F. Balavoine, B. Roques, and C. Llorens-Cortes (2008)
Hypertension 51, 1318-1325
   Abstract »    Full Text »    PDF »
Training-Induced Pressure Fall in Spontaneously Hypertensive Rats Is Associated With Reduced Angiotensinogen mRNA Expression Within the Nucleus Tractus Solitarii.
J. V. C. Felix and L. C. Michelini (2007)
Hypertension 50, 780-785
   Abstract »    Full Text »    PDF »
Tissue ACE Inhibitors for Secondary Prevention of Cardiovascular Disease in Patients With Preserved Left Ventricular Function: A Pooled Meta-analysis of Randomized Placebo-controlled Trials.
S. A. Saha, J. Molnar, and R. R. Arora (2007)
Journal of Cardiovascular Pharmacology and Therapeutics 12, 192-204
   Abstract »    PDF »
Role of the AT1A receptor in the CO2-induced stimulation of HCO3- reabsorption by renal proximal tubules.
Y. Zhou, P. Bouyer, and W. F. Boron (2007)
Am J Physiol Renal Physiol 293, F110-F120
   Abstract »    Full Text »    PDF »
A Cre-loxP solution for defining the brain renin-angiotensin system. Focus on "Targeted viral delivery of Cre recombinase induces conditional gene deletion in cardiovascular circuits of the mouse brain".
M. I. Phillips (2004)
Physiol Genomics 18, 1-3
   Full Text »    PDF »
Chronic Production of Angiotensin IV in the Brain Leads to Hypertension That Is Reversible With an Angiotensin II AT1 Receptor Antagonist.
N. Lochard, G. Thibault, D. W. Silversides, R. M. Touyz, and T. L. Reudelhuber (2004)
Circ. Res. 94, 1451-1457
   Abstract »    Full Text »    PDF »
Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: A potential treatment of salt-dependent hypertension.
M.-C. Fournie-Zaluski, C. Fassot, B. Valentin, D. Djordjijevic, A. Reaux-Le Goazigo, P. Corvol, B. P. Roques, and C. Llorens-Cortes (2004)
PNAS 101, 7775-7780
   Abstract »    Full Text »    PDF »
The Hypothalamus and Hypertension.
H. E. De Wardener (2001)
Physiol Rev 81, 1599-1658
   Abstract »    Full Text »    PDF »
Blockade of angiotensin AT1-receptors in the rostral ventrolateral medulla of spontaneously hypertensive rats reduces blood pressure and sympathetic nerve discharge.
A. M Allen (2001)
Journal of Renin-Angiotensin-Aldosterone System 2, S120-S124
   Abstract »    PDF »
Antisense Inhibition of Thyrotropin-Releasing Hormone Reduces Arterial Blood Pressure in Spontaneously Hypertensive Rats.
S. I. Garcia, A. L. Alvarez, P. I. Porto, V. M. Garfunkel, S. Finkielman, and C. J. Pirola (2001)
Hypertension 37, 365-370
   Abstract »    Full Text »    PDF »
Intravenous angiotensinogen antisense in AAV-based vector decreases hypertension.
X. Tang, D. Mohuczy, Y. C. Zhang, B. Kimura, S. M. Galli, and M. I. Phillips (1999)
Am J Physiol Heart Circ Physiol 277, H2392-H2399
   Abstract »    Full Text »    PDF »
Aminopeptidase A inhibitors as potential central antihypertensive agents.
A. Reaux, M. C. Fournie-Zaluski, C. David, S. Zini, B. P. Roques, P. Corvol, and C. Llorens-Cortes (1999)
PNAS 96, 13415-13420
   Abstract »    Full Text »    PDF »
Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen.
M. Schinke, O. Baltatu, M. Bohm, J. Peters, W. Rascher, G. Bricca, A. Lippoldt, D. Ganten, and M. Bader (1999)
PNAS 96, 3975-3980
   Abstract »    Full Text »    PDF »
Angiotensin II Type 1 Receptor–Mediated Inhibition of K+ Channel Subunit Kv2.2 in Brain Stem and Hypothalamic Neurons.
C. H. Gelband, J. D. Warth, H. S. Mason, M. Zhu, J. M. Moore, J. L. Kenyon, B. Horowitz, and C. Sumners (1999)
Circ. Res. 84, 352-359
   Abstract »    Full Text »    PDF »
Distinct Renin Isoforms Generated by Tissue-Specific Transcription Initiation and Alternative Splicing.
M. A. Lee-Kirsch, F. Gaudet, M. C. Cardoso, and K. Lindpaintner (1999)
Circ. Res. 84, 240-246
   Abstract »    Full Text »    PDF »
Kidney Aminopeptidase A and Hypertension, Part I : Spontaneously Hypertensive Rats.
D. P. Healy and L. Song (1999)
Hypertension 33, 740-745
   Abstract »    Full Text »    PDF »
Angiotensin, Thirst, and Sodium Appetite.
J. T. FITZSIMONS (1998)
Physiol Rev 78, 583-686
   Abstract »    Full Text »    PDF »
Central Overexpression of the TRH Precursor Gene Induces Hypertension in Rats : Antisense Reversal.
S. I. Garcia, P. I. Porto, A. L. Alvarez, V. N. Martinez, D. Shaurli, S. Finkielman, and C. J. Pirola (1997)
Hypertension 30, 759-766
   Abstract »    Full Text »
Brain "Ouabain" and Angiotensin II in Salt-Sensitive Hypertension in Spontaneously Hypertensive Rats.
B. S. Huang and F. H.H. Leenen (1996)
Hypertension 28, 1005-1012
   Abstract »    Full Text »
Inhibition of Hypertension by Peripheral Administration of Antisense Oligodeoxynucleotides.
D. Wielbo, A. Simon, M. I. Phillips, and S. Toffolo (1996)
Hypertension 28, 147-151
   Abstract »    Full Text »
Changes in the Baroreflex Control of Heart Rate Produced by Central Infusion of Selective Angiotensin Antagonists in Hypertensive Rats.
D. R. Oliveira, R. A.S. Santos, G. F.P. Santos, M. C. Khosla, and M. J. Campagnole-Santos (1996)
Hypertension 27, 1284-1290
   Abstract »    Full Text »
Permanent Inhibition of Angiotensinogen Synthesis by Antisense RNA Expression.
M. Schinke, M. Bohm, G. Bricca, D. Ganten, and M. Bader (1996)
Hypertension 27, 508-513
   Abstract »    Full Text »
Expression of Aminopeptidase A, an Angiotensinase, in Glomerular Mesangial Cells.
M. Troyanovskaya, L. Song, G. Jayaraman, and D. P. Healy (1996)
Hypertension 27, 518-522
   Abstract »    Full Text »
Comparison of Early and Late Start of Antihypertensive Agents and Baroreceptor Reflexes.
K. Kumagai, H. Suzuki, M. Ichikawa, M. Jimbo, M. Nishizawa, M. Ryuzaki, and T. Saruta (1996)
Hypertension 27, 209-218
   Abstract »    Full Text »
Thyrotropin-Releasing Hormone Hyperactivity in the Preoptic Area of Spontaneously Hypertensive Rats.
S.I. Garcia, S.M. Dabsys, V.N. Martinez, A. Delorenzi, D. Santajuliana, V.E. Nahmod, S. Finkielman, and C.J. Pirola (1995)
Hypertension 26, 1105-1110
   Abstract »    Full Text »
Angiotensin Peptides in Spontaneously Hypertensive and Normotensive Donryu Rats.
D. J. Campbell, A.-M. Duncan, A. Kladis, and S. B. Harrap (1995)
Hypertension 25, 928-934
   Abstract »    Full Text »
Differential Gene Expression of Renin and Angiotensinogen in the TGR(mREN-2)27 Transgenic Rat.
M. A. Lee, M. Bohm, S. Kim, S. Bachmann, J. Bachmann, M. Bader, and D. Ganten (1995)
Hypertension 25, 570-580
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)