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Science 26 August 1983:
Vol. 221. no. 4613, pp. 851 - 853
DOI: 10.1126/science.6879180
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Articles

Science, Vol 221, Issue 4613, 851-853
Copyright © 1983 by American Association for the Advancement of Science

articles

Bloom's syndrome: evidence for an increased mutation frequency in vivo

Vijayalaxmi, HJ Evans, JH Ray, and J German

The incidence of lymphocytes resistant to the purine analog 6-thioguanine was studied in seven patients with Bloom's syndrome. The mean frequency was 17.3 X 10(-4). The mean incidence in age- and sex-matched controls was 2.1 X 10(-4), so approximately eight times the normal number of 6-thioguanine-resistant lymphocytes were detected in Bloom's syndrome blood. The basis for this increase is unknown, but the inherent genomic instability demonstrated in the form of chromosomal aberrations is one possible explanation.


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