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Science 26 August 1983:
Vol. 221. no. 4613, pp. 823 - 828
DOI: 10.1126/science.6308762
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Articles

Science, Vol 221, Issue 4613, 823-828
Copyright © 1983 by American Association for the Advancement of Science

articles

Ivermectin: a potent new antiparasitic agent

WC Campbell, MH Fisher, EO Stapley, G Albers-Schonberg, and TA Jacob

Ivermectin is the 22,23-dihydro derivative of avermectin B1, a macrocyclic lactone produced by an actinomycete, Streptomyces avermitilis. It is active at extremely low dosage against a wide variety of nematode and arthropod parasites, apparently by virtue of its action on the mediation of neurotransmission by gamma-aminobutyric acid. It is now in commercial use in various countries for the treatment and control of parasites in cattle, horses, and sheep, and is expected to become available for use in swine and dogs. Since studies with the drug in man are in a preliminary stage, it is not yet known whether ivermectin will be useful in human medicine.


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Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection.
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Treatment of Onchocerciasis: The Ocular Effects of Ivermectin and Diethylcarbamazine.
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