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Science 19 August 1983:
Vol. 221. no. 4612, pp. 781 - 783
DOI: 10.1126/science.6224294
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Articles

Science, Vol 221, Issue 4612, 781-783
Copyright © 1983 by American Association for the Advancement of Science

articles

Down's syndrome in adults: brain metabolism

M Schwartz, R Duara, J Haxby, C Grady, BJ White, RM Kessler, AD Kay, NR Cutler, and SI Rapoport

The cerebral metabolic rate for glucose, as measured with positron emission tomography and fluorine-18-labeled 2-deoxy-D-glucose, was significantly higher in four healthy young subjects with trisomy 21 syndrome (Down's syndrome) than the mean rate in healthy young controls. The rate of cerebral glucose utilization in the frontal lobe of a 51-year-old subject with Down's syndrome was significantly lower than the rate in the young subjects with this syndrome, but approximated the rate in middle-aged controls. Thus glucose utilization by the brain appears to be excessive in young adults with Down's syndrome but may decline with age in some brain regions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia.
R. J. Haier, M. T. Alkire, N. S. White, M. R. Uncapher, E. Head, I. T. Lott, and C. W. Cotman (2003)
Neurology 61, 1673-1679
   Abstract »    Full Text »    PDF »
Alzheimer's Disease and Down's Syndrome: New Insights.
N. R. CUTLER, L. L. HESTON, P. DAVIES, J. V. HAXBY, and M. B. SCHAPIRO (1985)
Ann Intern Med 103, 566-578
   Abstract »    PDF »
Brain Metabolism in Autism: Resting Cerebral Glucose Utilization Rates as Measured With Positron Emission Tomography.
J. M. Rumsey, R. Duara, C. Grady, J. L. Rapoport, R. A. Margolin, S. I. Rapoport, and N. R. Cutler (1985)
Arch Gen Psychiatry 42, 448-455
   Abstract »    PDF »
Brain Imaging: Aging and Dementia.
N. R. CUTLER, R. DUARA, H. CREASEY, C. L. GRADY, J. V. HAXBY, M. B. SCHAPIRO, and S. I. RAPOPORT (1984)
Ann Intern Med 101, 355-369
   Abstract »    PDF »


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