Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 19 August 1983:
Vol. 221. no. 4612, pp. 775 - 777
DOI: 10.1126/science.6879177
Prev | Table of Contents | Next

Articles

Science, Vol 221, Issue 4612, 775-777
Copyright © 1983 by American Association for the Advancement of Science

articles

Cocaine-induced rotation: sex-dependent differences between left- and right-sided rats

SD Glick, PA Hinds, and RM Shapiro

Cocaine elicited dose-related rotation (circling) in naive rats. The maximum effect was greater than observed previously with other drugs. Overall, females were more sensitive to cocaine than males. However, right-biased females were more sensitive than left-biased females, whereas left-biased males were more sensitive than right-biased males. The results suggest that sex-dependent differences in brain asymmetry may be an important determinant of cocaine sensitivity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Influence of Ovarian Hormones and Estrous Cycle on the Behavioral Response to Cocaine in Female Rats.
S. L. Sell, J. M. Scalzitti, M. L. Thomas, and K. A. Cunningham (2000)
J. Pharmacol. Exp. Ther. 293, 879-886
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)