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Science 19 August 1983:
Vol. 221. no. 4612, pp. 773 - 775
DOI: 10.1126/science.6879176
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Articles

Science, Vol 221, Issue 4612, 773-775
Copyright © 1983 by American Association for the Advancement of Science

articles

Cortical dopaminergic involvement in cocaine reinforcement

NE Goeders and JE Smith

Neuronal systems involved in the initiation of cocaine reinforcement were investigated by identifying brain sites where direct application of the drug was reinforcing. This was accomplished by allowing rats to self-administer picomolar concentrations of cocaine into discrete brain regions. The medial prefrontal cortex supported self-administration, while the nucleus accumbens and ventral tegmental area did not. Self-administration could be attenuated by including equimolar concentrations of the dopaminergic D2-receptor antagonist sulpiride in the microinjection system. These results imply that cocaine reinforcement is mediated in part through a direct action on mesocortical dopaminergic receptors.


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