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Science 19 August 1983:
Vol. 221. no. 4612, pp. 766 - 769
DOI: 10.1126/science.6879174
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Articles

Science, Vol 221, Issue 4612, 766-769
Copyright © 1983 by American Association for the Advancement of Science

articles

Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome

LA Leinwand, RE Fournier, B Nadal-Ginard, and TB Shows

Cloned myosin heavy chain DNA probes from rat and human were hybridized to restriction endonuclease digests of genomic DNA from somatic cell hybrids and their parental cells. The mouse myosin heavy chain genes detectable by this assay were located on chromosome 11, and three different human sarcomeric myosin heavy chain genes were mapped to the short arm of chromosome 17. A synteny between myosin heavy chain and two unrelated markers, thymidine kinase and galactokinase, was found to be preserved in the rodent and human genomes.


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