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Science 19 August 1983:
Vol. 221. no. 4612, pp. 762 - 764
DOI: 10.1126/science.6308760
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Articles

Science, Vol 221, Issue 4612, 762-764
Copyright © 1983 by American Association for the Advancement of Science

articles

Entamoeba histolytica causes intestinal secretion: role of serotonin

K McGowan, A Kane, N Asarkof, J Wicks, V Guerina, J Kellum, S Baron, AR Gintzler, and M Donowitz

Lysates of the protozoan parasite Entamoeba histolytica altered active electrolyte transport when present on the serosal surface of rabbit ileum and rat colon. The lysate-induced effects on electrolyte transport were similar to those caused by serotonin, and were blocked by bufotenine, an analog known to inhibit the action of serotonin. The transport effects were partially inhibited by antibody to serotonin. The amebic lysates were shown to contain serotonin by radioimmunoassay, high-performance liquid chromatography, and thin-layer chromatography. These results suggest that the serotonin present in Entamoeba histolytica may be important in the diarrhea seen in amebiasis.


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Changes in 5-HT-mediated pathways in radiation-induced attenuation and recovery of ion transport in rat colon.
A. Francois, B. Ksas, P. Gourmelon, and N. M. Griffiths (2000)
Am J Physiol Gastrointest Liver Physiol 278, G75-G82
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Science. ISSN 0036-8075 (print), 1095-9203 (online)